Published 01/01/1998
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Antimicrobial Susceptibility Testing of Dermatophytes - Comparison of the Agar Macrodilution and Broth Microdilution Tests

K.Hans , N.M. , S.V. , R.J. , A.Dietrich

Keywords
Introduction
While the number of avail-able antimycotics has increased considerably over the last years, more and more reports have been published stating recalcitrance to therapy or even resistance of a dermatophyte against the antimicrobial agents used. In order to determine the capability of antimy-cotics to eradicate dermatophytes, the imple-mentation of in vitro susceptibility testing may prove helpful, as is now established with Candida species. With griseofulvin, a failure of therapy corresponding to in vitro resistance has been shown.
Resume
Fifty dermatophyte strains, recently obtained from clinical material, belonging to 4 different species were examined for their susceptibility to 5 systemic or topical antimycotic agents using both an agar macrodilution and a broth microdilution test.
Method
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Results
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Conclusion
Fifty dermatophyte strains, recently obtained from clinical material, belonging to 4 different species were examined for their susceptibility to 5 systemic or topical antimycotic agents using both an agar macrodilution and a broth microdilution test. Antimycotics compared were griseofulvin, itraconazole, sertaconazole, terbinafine and ciclopiroxolamine. A comparison of the minimum inhibitory concentrations (MIC) clearly showed differences between the two test methods applied. For all 5 antimycotics, MIC data were three- to seventyfold lower in the microdilution test system. These differences, depending on the test method, have to be taken into account when comparing MIC data in the literature or when relating the in vitro data to the tissue concentrations determined in vivo.
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